Tuning excited state of bipyridyl platinum(II) complexes with bio-active flavonolate ligand: Structures, photoreactivity, and DFT calculations

被引：1
|
作者：
Han, Xiaozhen [1 ]
Sahihi, Mehdi [2 ]
Whitfield, Sarah [1 ]
Jimenez, Ivan [1 ]
机构：
[1] Stephen F Austin State Univ, Dept Chem, Nacogdoches, TX 75962 USA
[2] Univ Gustave Eiffel, CNRS, UPEC, MSME, F-77454 Marne La Vallee, France
来源：
INORGANICA CHIMICA ACTA | 2020年 / 513卷
关键词：
Bipyridyl platinum (II) complexes; Flavonols; Metal/ligand-to-ligand charge transfer; ENZYME-SUBSTRATE COMPLEX; ANTICANCER DRUG; PHOTOINDUCED OXYGENATION; CRYSTAL-STRUCTURES; DIIMINE COMPLEXES; FUNCTIONAL MODELS; CATECHOLATE; INHIBITION; COPPER; IRON;
D O I：
10.1016/j.ica.2020.119952
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Platinum(II) complexes with coordinated bio-active molecules that can undergo photo-induced oxygenation are finding applications in photoactivated chemotherapy (PCT). A series of bipyridyl(bpy) Pt(II) complexes with ligand flavonolate (fla(-)) [Pt(II)BpyFla(R)][BF4] [BF4] (R = p- OMe (1), p-Me (2), p-H (3)) were prepared and characterized. Their photochemical and photophysical properties were investigated. Complexes 1-3 exhibit emission at similar to 530 nm, as compared to the analogous [Pd(II)BpyFla(R)][BF4] with no emission upon irradiation. In addition, Pt(II) complexes undergo oxygenation reaction with oxygen with near visible light, indicating photocleavage of ligand flavonolate. Carbon monoxide(CO) release was observed by deoxymyoglobin from oxygenation of Pt(II) flavonolate complexes. Density functional theory calculations predict a mixed, Pt/fla- to bpy, metal/ligand-to-ligand charge transfer (ML-LCT) state in complexes 1-3.
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页数：6
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