Solubility of Tadalafil in Pharmaceutical Solvent Mixtures at 298.2K

被引：3

作者：

Farjami, Afsaneh ^{[1
]}

Jouyban, Abolghasem ^{[2
,3
,4
]}

机构：

[1] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz 51664, Iran

[3] Tabriz Univ Med Sci, Fac Pharm, Tabriz 51664, Iran

[4] Tabriz Univ Med Sci, Kimia Idea Pardaz Azarbayjan Sci Based Co, Tabriz 51664, Iran

来源：

CHEMICAL ENGINEERING COMMUNICATIONS | 2015年 / 202卷 / 11期

关键词：

Co-solvency; Jouyban-acree model; Solubility prediction; Tadalafil; WATER-COSOLVENT MIXTURES; TERNARY MIXTURES; PEGS; 200; BINARY; PREDICTION; ENHANCEMENT; ETHANOL; MODELS; GLYCOL; DRUGS;

D O I：

10.1080/00986445.2014.956738

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The experimental solubility of tadalafil in binary mixtures of ethanol (EtOH) + water, propylene glycol (PG) + water, polyethylene glycol 200 (PEG 200) + water, polyethylene glycol 400 (PEG 400) + water, and ternary mixtures of PEG 200 + PG + EtoH at 298.2 K were assessed. The experimental data were fitted to the Jouyban Acree model. The mean percent deviations (MPD) of the back-calculated solubilities for EtOH + water, PG +water, PEG 200 + water, PEG 400 + water, and PEG 200 + PG + EtOH mixtures were 7.4%, 11.3%, 14.0%, 18.5%, and 5.6%, respectively and the overall MPD was 11.0%.

引用

页码：1522 / 1527

页数：6

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