The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival

被引：99
|
作者：
Wang, Xiao [2 ]
Asplund, A. Charlotta [3 ]
Porwit, Anna [4 ,5 ]
Flygare, Jenny [2 ]
Smith, C. I. Edvard [3 ]
Christensson, Birger [2 ]
Sander, Birgitta [1 ,2 ]
机构：
[1] Karolinska Univ, Huddinge Hosp, Dept Pathol, SE-14186 Stockholm, Sweden
[2] Karolinska Inst, Div Pathol, Dept Lab Med, Stockholm, Sweden
[3] Karolinska Inst, Clin Res Ctr, Dept Lab Med, Stockholm, Sweden
[4] Karolinska Inst, Div Pathol, Dept Pathol & Oncol, Stockholm, Sweden
[5] Karolinska Univ, Hosp Solna, Stockholm, Sweden
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2008年 / 143卷 / 02期
基金：
瑞典研究理事会;
关键词：
mantle cell lymphoma; sox11; nuclear expression; survival; proliferation;
D O I：
10.1111/j.1365-2141.2008.07329.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Gene expression analysis demonstrated high expression of the neuronal transcription factor SOX11 in mantle cell lymphoma (MCL). In contrast to follicular lymphoma, small lymphocytic lymphoma and reactive lymphoid tissue, most MCLs tested (48/53 patients) expressed sox11 protein in the nucleus. Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL.
引用
收藏
页码：248 / 252
页数：5
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