Interaction of cellular prion and stress-inducible protein 1 promotes neuritogenesis and neuroprotection by distinct signaling pathways

被引:217
|
作者
Lopes, MH
Hajj, GNM
Muras, AG
Mancini, GL
Castro, RMPS
Ribeiro, KCB
Brentani, RR
Linden, R
Martins, VR
机构
[1] Hosp Canc, Ctr Tratamento & Pesquisa, BR-01509010 Sao Paulo, Brazil
[2] Univ Fed Rio de Janeiro, Inst Biofis, Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, Brazil
来源
JOURNAL OF NEUROSCIENCE | 2005年 / 25卷 / 49期
基金
巴西圣保罗研究基金会;
关键词
cellular prion protein; MAPK; neuritogenesis; neuroprotection; PKA; STI1;
D O I
10.1523/JNEUROSCI.2313-05.2005
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Understanding the physiological function of the cellular prion (PrPc) depends on the investigation of PrPc- interacting proteins. Stress-inducible protein 1 (STI1) is a specific PrPc ligand that promotes neuroprotection of retinal neurons through cAMP-dependent protein kinase A (PKA). Here, weexamined the signaling pathways and functional consequences of the PrPc interaction with STI1 in hippocampal neurons. Both PrPc and STI1 are abundantly expressed and highly colocalized in the hippocampus in situ, indicating that they can interact in vivo. Recombinant STI1 (His(6)-STI1) added to hippocampal cultures interacts with PrPc at the neuronal surface and elicits neuritogenesis in wild-type neurons but not in PrPc- null cells. This effect was abolished by antibodies against either PrPc or STI1 and was dependent on the STI1 domain that binds PrPc. Binding of these proteins induced the phosphorylation/activation of the mitogenactivated protein kinase, which was essential for STI1-promoted neuritogenesis. His(6)-STI1, but not its counterpart lacking the PrPc binding site, prevented cell death via PKA activation. These results demonstrate that two parallel effects of the PrPc-STI1 interaction, neuritogenesis and neuroprotection, are mediated by distinct signaling pathways.
引用
收藏
页码:11330 / 11339
页数:10
相关论文
共 50 条
  • [21] The role of stress-inducible protein 1 (STI1) in cellular resilience and Alzheimer's disease
    Lackie, R.
    Marques-Lopes, J.
    Ostapchenko, V.
    Beraldo, F.
    Fan, J.
    Martins, V.
    Prado, V.
    Prado, M.
    JOURNAL OF NEUROCHEMISTRY, 2017, 142 : 207 - 208
  • [22] Structural characterization and biological implications of cellular prion in complex with stress inducible protein 1
    Maciejewski, Andrew
    Prado, Marco
    Choy, Wing-Yiu
    PRION, 2012, 6 : 125 - 125
  • [23] Cellular prion protein is required for neuritogenesis: fine-tuning of multiple signaling pathways involved in focal adhesions and actin cytoskeleton dynamics
    Alleaume-Butaux, Aurelie
    Dakowski, Caroline
    Pietri, Mathea
    Mouillet-Richard, Sophie
    Launay, Jean-Marie
    Kellermann, Odile
    Schneider, Benoit
    CELL HEALTH AND CYTOSKELETON, 2013, 5 : 1 - 12
  • [24] MODULATION OF ASTROCYTE-MEDIATED NEUROTOXICITY BY PRION PROTEIN AND STRESS-INDUCIBLE PROTEIN I IN A MODEL OF ALS
    Barbeito, A. G.
    Martinez-Palma, L.
    Cassina, P.
    Hajj, G. N.
    Brentani, R. R.
    Barbeito, L.
    Martins, V. R.
    GLIA, 2009, 57 (13) : S92 - S92
  • [25] RETRACTION: Antibodies to cellular prion protein and its cognate ligand stress-inducible protein 1 in systemic lupus erythematosus (Retraction of Vol 93, Pg 861, 2020)
    Carvalho, J. F.
    Viana, V. S. T.
    Leon, E. P.
    Bonfa, E.
    Pasoto, S. G.
    Martins, V. R.
    LUPUS, 2020, 29 (11) : 1487 - 1487
  • [26] Formation of a metastable stress-inducible prion by the yeast short-lived actin associated protein
    Chernova, Tatiana A.
    Kiktev, Denis A.
    Romanyuk, Andrey V.
    Shanks, John R.
    Ali, Moiez
    Ghosh, Abheek
    Yang, Zhen
    Kim, Dami
    Mang, Maggie
    Chernoff, Yury O.
    Wilkinson, Keith D.
    PRION, 2016, 10 : S66 - S67
  • [27] Stress-inducible Protien-1 promotes metastasis of gastric cancer via Wnt/β-catenin signaling pathway
    Huang, Linlin
    Zhai, Ertao
    Cai, Shirong
    Lin, Yi
    Liao, Junbin
    Jin, Huilin
    Peng, Sui
    Xu, Lixia
    Chen, Minhu
    Zeng, Zhirong
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2018, 37
  • [28] The Prion Protein Ligand, Stress-Inducible Phosphoprotein 1, Regulates Amyloid-β Oligomer Toxicity (October, 16552, 2013)
    Ostapchenko, Valeriy G.
    Beraldo, Flavio H.
    Mohammad, Amro H.
    Xie, Yu-Feng
    Hirata, Pedro H. F.
    Magalhaes, Ana C.
    Lamour, Guillaume
    Li, Hongbin
    Maciejewski, Andrzej
    Belrose, Jullian C.
    Teixeira, Bianca L.
    Fahnestock, Margaret
    Ferreira, Sergio T.
    Cashman, Neil R.
    Hajj, Glaucia N. M.
    Jackson, Michael F.
    Choy, Wing-Yiu
    MacDonald, John F.
    Martins, Vilma R.
    Prado, Vania F.
    Prado, Marco A. M.
    JOURNAL OF NEUROSCIENCE, 2015, 35 (04): : 1816 - 1816
  • [29] Neuritogenesis-The prion protein controls beta1 integrin signaling activity
    Dakowski, Caroline
    Loubet, Damien
    Pietri, Mathea
    Pradines, Elodie
    Bernard, Sophie
    Callebert, Jacques
    Osorio, Hector Hardila
    Mouillet-Richard, Sophie
    Launay, Jean-Marie
    Kellermann, Odile
    Schneider, Benoit
    PRION, 2012, 6 : 115 - 116
  • [30] PRION PROTEIN AND STRESS INDUCIBLE PROTEIN 1 MODULATE ASTROCYTE DEVELOPMENT
    Lima, F. R. S.
    Arantes, C. P.
    Nomizo, R.
    Lopes, M. M.
    Hajj, G. N.
    Martins, V. R.
    GLIA, 2009, 57 (13) : S62 - S62