MicroRNAs: 'ribo-regulators' of glucose homeostasis

被引:106
|
作者
Gauthier, BR [1 ]
Wollheim, CB [1 ]
机构
[1] Univ Geneva, Med Ctr, Dept Cell Physiol & Metab, CH-1211 Geneva 4, Switzerland
关键词
D O I
10.1038/nm0106-36
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Insulin secretion regulates glucose homeostasis and its dysregulation causes type 2 diabetes. Short noncoding microRNAs have now been shown to control exocytosis, the final event in insulin secretion. This discovery opens potential perspectives for diabetes therapy.
引用
收藏
页码:36 / 38
页数:4
相关论文
共 50 条
  • [41] Identification of Warm-Sensitive Neurons in the Hypothalamic Preoptic Area as Powerful Regulators of Glucose Homeostasis
    Deem, Jennifer D.
    Ogimoto, Kayoko
    Velasco, Kevin R.
    Damian, Vincent
    Knight, Zachary
    Schwartz, Michael W.
    Morton, Gregory J.
    DIABETES, 2018, 67
  • [42] microRNAs: Tiny regulators with great potential
    Ambros, V
    CELL, 2001, 107 (07) : 823 - 826
  • [43] MicroRNAs as regulators of root development and architecture
    Khan, Ghazanfar A.
    Declerck, Marie
    Sorin, Celine
    Hartmann, Caroline
    Crespi, Martin
    Lelandais-Briere, Christine
    PLANT MOLECULAR BIOLOGY, 2011, 77 (1-2) : 47 - 58
  • [44] MicroRNAs: key regulators of stem cells
    Vamsi K. Gangaraju
    Haifan Lin
    Nature Reviews Molecular Cell Biology, 2009, 10 : 116 - 125
  • [45] MicroRNAs: A new class of gene regulators
    Guarnieri, Douglas J.
    Dileone, Ralph J.
    ANNALS OF MEDICINE, 2008, 40 (03) : 197 - 208
  • [46] MicroRNAs as Important Regulators of Exercise Adaptation
    Silva, Gustavo J. J.
    Bye, Anja
    el Azzouzi, Hamid
    Wisloff, Ulrik
    PROGRESS IN CARDIOVASCULAR DISEASES, 2017, 60 (01) : 130 - 151
  • [47] MicroRNAs as regulators of mitochondrial dysfunction and obesity
    Murri, Mora
    el Azzouzi, Hamid
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2018, 315 (02): : H291 - H302
  • [48] Warm Responsive Neurons in the Hypothalamic Preoptic Area are Potent Regulators of Glucose Homeostasis in Male Mice
    Deem, Jennifer D.
    Phan, Bao Anh
    Ogimoto, Kayoko
    Cheng, Alice
    Bryan, Caeley L.
    Scarlett, Jarrad M.
    Schwartz, Michael W.
    Morton, Gregory J.
    ENDOCRINOLOGY, 2023, 164 (07)
  • [49] Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis
    Mihaylova, Maria M.
    Vasquez, Debbie S.
    Ravnskjaer, Kim
    Denechaud, Pierre-Damien
    Yu, Ruth T.
    Alvarez, Jacqueline G.
    Downes, Michael
    Evans, Ronald M.
    Montminy, Marc
    Shaw, Reuben J.
    CELL, 2011, 145 (04) : 607 - 621
  • [50] G Protein-Coupled Receptors as Regulators of Glucose Homeostasis and Therapeutic Targets for Diabetes Mellitus
    Tao, Ya-Xiong
    Liang, Xu-Fang
    GLUCOSE HOMEOSTATIS AND THE PATHOGENESIS OF DIABETES MELLITUS, 2014, 121 : 1 - 21