Immunochemical assay of glia-specific antigens as a criterion for blood-brain barrier permeability in rats during acute intoxication with sodium barbital

被引：1
|
作者：
Ryabukhin, IA
Artemkina, IV
Gurina, OI
Sergienko, VI
Chekhonin, VP
机构：
[1] VP Serbskii Res Ctr Social & Forens Med, Moscow, Russia
[2] Russia Minist Hlth, Inst Physicochem Med, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 131卷 / 05期
关键词：
blood-brain barrier; glia-specific antigens; GFAP AND alpha(2)GP; sodium barbital;
D O I：
10.1023/A:1017904805547
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Enzyme immunoassay showed penetration of two glia-specific antigens, glial fibrillar acid protein GFAP and specific brain glycoprotein alpha (2)GP, through the blood-brain barrier in rats treated with toxic doses of sodium barbital. The permeability of the blood-brain barrier was completely normalized 3 days after treatment. This method can be used in clinical practice for evaluation of the severity of impairment and dynamics of normalization of blood-brain barrier properties during acute intoxication with barbiturates.
引用
收藏
页码：502 / 504
页数：3
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