Immunochemical assay of glia-specific antigens as a criterion for blood-brain barrier permeability in rats during acute intoxication with sodium barbital

被引：1
|
作者：
Ryabukhin, IA
Artemkina, IV
Gurina, OI
Sergienko, VI
Chekhonin, VP
机构：
[1] VP Serbskii Res Ctr Social & Forens Med, Moscow, Russia
[2] Russia Minist Hlth, Inst Physicochem Med, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 131卷 / 05期
关键词：
blood-brain barrier; glia-specific antigens; GFAP AND alpha(2)GP; sodium barbital;
D O I：
10.1023/A:1017904805547
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Enzyme immunoassay showed penetration of two glia-specific antigens, glial fibrillar acid protein GFAP and specific brain glycoprotein alpha (2)GP, through the blood-brain barrier in rats treated with toxic doses of sodium barbital. The permeability of the blood-brain barrier was completely normalized 3 days after treatment. This method can be used in clinical practice for evaluation of the severity of impairment and dynamics of normalization of blood-brain barrier properties during acute intoxication with barbiturates.
引用
收藏
页码：502 / 504
页数：3
相关论文
共 50 条
  • [1] Immunochemical Assay of Glia-Specific Antigens as a Criterion for Blood-Brain Barrier Permeability in Rats during Acute Intoxication with Sodium Barbital
    I. A. Ryabukhin
    I. V. Artemkina
    O. I. Gurina
    V. I. Sergienko
    V. P. Chekhonin
    Bulletin of Experimental Biology and Medicine, 2001, 131 : 502 - 504
  • [2] ENZYME-IMMUNOASSAY OF SPECIFIC BRAIN ANTIGENS AS A CRITERION OF BLOOD-BRAIN-BARRIER PERMEABILITY IN RATS WITH ACUTE CEREBRAL-ISCHEMIA
    CHEKHONIN, VP
    MOROZOV, GV
    MORKOVKIN, VM
    BLIZNYUKOVA, AS
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1988, 105 (05) : 694 - 696
  • [3] Effect of aluminum on the blood-brain barrier permeability in acute and chronically hyperglycemic rats
    M. Küçük
    R. B. Kalayci
    A. Çevik
    I. Elmas
    M. Kaya
    Biological Trace Element Research, 2001, 80 : 181 - 189
  • [4] Effect of aluminum on the blood-brain barrier permeability in acute and chronically hyperglycemic rats
    Kücük, M
    Kalayci, RB
    Cevik, A
    Elmas, I
    Kaya, M
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2001, 80 (02) : 181 - 189
  • [5] Effects of acute hypoxia and hyperthermia on the permeability of the blood-brain barrier in adult rats
    Natah, Sirajedin S.
    Srinivasan, Sathya
    Pittman, Quentin
    Zhao, Zonghang
    Dunn, Jeff F.
    JOURNAL OF APPLIED PHYSIOLOGY, 2009, 107 (04) : 1348 - 1356
  • [6] Magnesium sulphate treatment decreases blood-brain barrier permeability during acute hypertension in pregnant rats
    Euser, Anna G.
    Bullinger, Lisa
    Cipolla, Marilyn J.
    EXPERIMENTAL PHYSIOLOGY, 2008, 93 (02) : 254 - 261
  • [7] Effects of acute cold exposure on blood-brain barrier permeability in acute and chronic hyperglycemic rats
    Arican, N
    Kaya, M
    Kalayci, R
    Kucuk, M
    Cimen, V
    Elmas, L
    FORENSIC SCIENCE INTERNATIONAL, 2002, 125 (2-3) : 137 - 141
  • [8] Mesenchymal stem cells decrease blood-brain barrier permeability in rats with severe acute pancreatitis
    Lin, Ronggui
    Li, Ming
    Luo, Meiqin
    Teng, Tianhong
    Pan, Yu
    Huang, Heguang
    CELLULAR & MOLECULAR BIOLOGY LETTERS, 2019, 24 (1)
  • [9] Effects of profound hypothermia on the blood-brain barrier permeability in acute and chronically ethanol treated rats
    Elmas, I
    Küçük, M
    Kalayci, RB
    Cevik, A
    Kaya, M
    FORENSIC SCIENCE INTERNATIONAL, 2001, 119 (02) : 212 - 216
  • [10] Streptozotocin-induced diabetes progressively increases blood-brain barrier permeability in specific brain regions in rats
    Huber, Jason D.
    VanGilder, Reyna L.
    Houser, Kimberly A.
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2006, 291 (06): : H2660 - H2668
12345