The thymic repertoire of neuroendocrine self-antigens: Physiological implications in T-cell life and death

被引：57
|
作者：
Martens, H
Goxe, B
Geenen, V
机构：
来源：
IMMUNOLOGY TODAY | 1996年 / 17卷 / 07期
关键词：
D O I：
10.1016/0167-5699(96)10023-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
During phylogeny and ontogeny, the thymus appears as a crucial meeting point between the neuroendocrine and immune systems; through cryptocrine intercellular communication, thymic neuroendocrine-related precursors can influence the early steps of the immune response, while T-cell precursors are educated to recognize the principal neuroendocrine families. Here we summarize the observations that support the dual role of the thymic repertoire of neuroendocrine-related polypeptide precursors in T-cell differentiation.
引用
收藏
页码：312 / 317
页数：6
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