Metal complexation and DNA cleavage activities of N-substituted hydroxamic acids

被引：0

作者：

Ghosh, KK ^{[1
]}

Tamrakar, P ^{[1
]}

Jadhav, VR ^{[1
]}

机构：

[1] Pt Ravishankar Shukia Univ, Sch Studies Chem, Raipur 492010, Madhya Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY | 1999年 / 38卷 / 07期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydroxamic acid, RCON(R')OH, is a bidentate oxygen ligand possessing affinity for a variety of metal ions. The Cu(II) complexes of three N-substituted hydroxamic acids [R=C6H5; R'=C6H5, 4-CH3 - C6H4 and R'= C6H5.CH2 ] have been synthesized and characterized. Their DNA cleavage activities have been investigated using plasmid DNA. An oxidative mechanism for DNA cleavage by hydroxy radicals via abstraction of a H atom from sugar unit has been proposed.

引用

页码：712 / 715

页数：4

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