Myofibroblasts and local angiotensin II in rat cardiac tissue repair

被引:65
|
作者
Weber, KT
Sun, Y
Katwa, LC
机构
[1] Department of Internal Medicine, Univ. of Missouri Hlth. Sci. Center, Columbia, MO
关键词
myofibroblast; angiotensin II; tissue repair; collagen; angiotensin converting enzyme;
D O I
10.1016/S1357-2725(96)00116-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Tissue repair is a fundamental property of vascularized tissue. At sites of injury, phenotypically transformed fibroblast-like cells are responsible for fibrous tissue formation, expressed principally as type I and III fibrillar collagens. These cells are termed myofibroblasts because they contain alpha-smooth muscle actin microfilaments and are contractile. In vivo studies of injured rat cardiac tissues and in vitro cell culture studies have shown that such fibroblast-like cells contain requisite components for angiotensin peptide generation and angiotensin II receptors. Such locally generated angiotensin II acts in an autocrine/paracrine manner to regulate collagen turnover and thereby tissue homeostasis in injured tissue. (C) 1997 published by Elsevier Science Ltd.
引用
收藏
页码:31 / 42
页数:12
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