RHEUMATOID ARTHRITIS Obesity impairs efficacy of anti-TNF therapy in patients with RA

被引：18
|
作者：
Gonzalez-Gay, Miguel A. [1 ]
Gonzalez-Juanatey, Carlos [2 ]
机构：
[1] Hosp Univ Marques de Valdecilla, IFIMAV, Div Rheumatol, Santander 39008, Spain
[2] Hosp Univ Lucus Augusti, Div Cardiol, Lugo 27003, Spain
来源：
NATURE REVIEWS RHEUMATOLOGY | 2012年 / 8卷 / 11期
关键词：
INSULIN-RESISTANCE; SENSITIVITY;
D O I：
10.1038/nrrheum.2012.158
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Insulin resistance is closely associated with an increased risk of subclinical atherosclerosis in patients with rheumatoid arthritis (RA). Anti-TNF therapy reduces insulin resistance and improves insulin sensitivity in patients with severe RA. New findings have shown, however, that the efficacy of these agents in this regard is impaired by obesity. Gonzalez-Gay, M. A. & Gonzalez-Juanatey, C. Nat. Rev. Rheumatol. 8, 641-642 (2012); published online 25 September 2012; doi:10.1038/nrrheum.2012.158
引用
收藏
页码：641 / 642
页数：3
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