Role of Tropomyosin in the Regulation of Contraction in Smooth Muscle

被引：0
|
作者：
Marston, Steve [1 ]
El-Mezgueldi, M. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England
来源：
TROPOMYOSIN | 2008年 / 644卷
基金：
英国惠康基金;
关键词：
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Smooth muscle contraction is due to the interaction of myosin filaments with thin filaments. Thin filaments are composed of actin, tropomyosin, caldesmon and calmodulin in ratios 14:2:1:1. Tissue specific isoforms of alpha and beta tropomyosin are expressed in smooth muscle. Compared with skeletal muscle tropomyosin, the cooperative activation of actomyosin is enhanced by smooth muscle tropomyosin: cooperative unit size is 10 and the equilibrium between on and off states is shifted towards the on state. The smooth muscle-specific actin-binding protein caldesmon, together with calmodulin regulates the activity of the thin filament in response to Ca2+. Caldesmon and calmodulin control the tropomyosin-mediated transition between on and off activity states.
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页码：110 / 123
页数：14
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