In Vivo Efficacy of Daptomycin against Methicillin-Resistant Staphylococcus aureus in a Mouse Model of Hematogenous Pulmonary Infection

被引：15
|
作者：
Harada, Yosuke [1 ,2 ]
Yanagihara, Katsunori [1 ,2 ]
Yamada, Koichi [1 ,2 ]
Migiyama, Yohei [1 ,2 ]
Nagaoka, Kentaro [1 ,2 ]
Morinaga, Yoshitomo [1 ,2 ]
Nakamura, Shigeki [2 ]
Imamura, Yoshifumi [2 ]
Hasegawa, Hiroo [1 ]
Miyazaki, Taiga [2 ]
Izumikawa, Koichi [2 ]
Kakeya, Hiroshi [2 ]
Kohno, Shigeru [2 ,3 ]
机构：
[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Lab Med, Nagasaki 852, Japan
[2] Nagasaki Univ, Grad Sch Biomed Sci, Dept Internal Med 2, Nagasaki 852, Japan
[3] Nagasaki Univ, Global COE Program, Nagasaki 852, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 06期
关键词：
BLOOD-STREAM INFECTIONS; VANCOMYCIN; PHARMACOKINETICS; ENDOCARDITIS;
D O I：
10.1128/AAC.02331-12
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Daptomycin is inactivated by pulmonary surfactant, but its effectiveness in hematogenous pulmonary infection has been poorly studied. The potential therapeutic application was evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) hematogenous pulmonary infection mouse model. Compared with control results, daptomycin improved survival (P < 0.001) and decreased the number of abscesses and bacteria in the lungs (P < 0.01). Daptomycin may be an effective therapeutic option for MRSA hematogenous pulmonary infection.
引用
收藏
页码：2841 / 2844
页数：4
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