Synthesis of novel water soluble onium salts and thieno[3,4-c] thiolactones -: precursors of conductive materials derived from substituted 2-aminothiophenes

The synthetic utility in the area of synthesis of "smart" conductive materials of the easily accessible 2-aminothiophenes is described. Simple protection of amino group and subsequent radical bromination leads to brominated intermediates. The novel 4-bromomethylthiophene derivatives easily enter into reaction with tertiary amines and thiourea to give ammonium and thiouronium salts - novel water-soluble thiophenes. Thiouronium salts are predisposed to deliver substituted thieno[3,4-c]thiolactone derivatives, which are attractive from the point of view of their further utilization in the synthesis of thieno[3,4-c]thiophenes. Each of the mentioned compounds showed bioactivity as well as propensity to be polymerized to conductive oligomers and polymers.