Substituted coumarins as potent 5-lipoxygenase inhibitors

被引：42

作者：

Grimm, EL ^{[1
]}

Brideau, C ^{[1
]}

Chauret, N ^{[1
]}

Chan, CC ^{[1
]}

Delorme, D ^{[1
]}

Ducharme, Y ^{[1
]}

Ethier, D ^{[1
]}

Falgueyret, JP ^{[1
]}

Friesen, RW ^{[1
]}

Guay, J ^{[1
]}

Hamel, P ^{[1
]}

Riendeau, D ^{[1
]}

Soucy-Breau, C ^{[1
]}

Tagari, P ^{[1
]}

Girard, Y ^{[1
]}

机构：

[1] Merck Frosst Ctr Therapeut Res, Kirkland, PQ H9H 3L1, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 09期

关键词：

5-lipoxygenase; leukotrienene inhibitor; coumarin; structure-activity relationship;

D O I：

10.1016/j.bmcl.2006.01.085

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure-activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2528 / 2531

页数：4

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