Synthesis of pertrifluoromethyl pyridazine derivatives via a tandem reaction of aryldiazonium salts with hexafluoroacetylacetone

被引：10
|
作者：
Wu, Wei [1 ,2 ]
Han, Xiaoyan [3 ]
Weng, Zhiqiang [1 ,2 ]
机构：
[1] Fuzhou Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Peoples R China
[2] Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Electrochem Energy Storage Ma, Fuzhou 350108, Peoples R China
[3] Soochow Univ, Testing & Anal Ctr, Suzhou 215123, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 21期
基金：
中国国家自然科学基金;
关键词：
EFFICIENT SYNTHESIS; FLUORINE; TRIFLUOROMETHYLATION; CHEMISTRY;
D O I：
10.1039/d0qo00955e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new strategy for the construction of pertrifluoromethyl pyridazine derivatives is presented. The tandem reaction starts from the condensation of arenediazonium salts with hexafluoroacetylacetone leading to the formation of pertrifluoromethyl pyridazinols, which readily undergo electrophilic substitution reactions with phenols to afford benzo[5,6]chromeno[3,4-c]pyridazine products in the presence of concd H2SO4.
引用
收藏
页码：3499 / 3504
页数：6
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