Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis

被引：33

作者：

Morfopoulou, Sofia ^{[1
]}

Mee, Edward T. ^{[2
]}

Connaughton, Sarah M. ^{[2
]}

Brown, Julianne R. ^{[3
]}

Gilmour, Kimberly ^{[4
]}

Chong, W. K. 'Kling' ^{[5
]}

Duprex, W. Paul ^{[6
]}

Ferguson, Deborah ^{[2
]}

Hubank, Mike ^{[7
]}

Hutchinson, Ciaran ^{[8
]}

Kaliakatsos, Marios ^{[9
]}

McQuaid, Stephen ^{[10
,11
]}

Paine, Simon ^{[8
,12
]}

Plagnol, Vincent ^{[13
]}

Ruis, Christopher ^{[1
]}

Virasami, Alex ^{[8
]}

Zhan, Hong ^{[14
]}

Jacques, Thomas S. ^{[8
,15
]}

Schepelmann, Silke ^{[2
]}

Qasim, Waseem ^{[16
,17
]}

Breuer, Judith ^{[1
,3
]}

机构：

[1] UCL, Div Infect & Immun, Cruciform Bldg,Gower St, London WC1E 6BT, England

[2] Natl Inst Biol Stand & Controls, Div Virol, Potters Bar EN6 3QG, Herts, England

[3] NHS Fdn Trust, Microbiol Virol & Infect Control, Great Ormond St Hosp Children, London WC1N 3JH, England

[4] NHS Fdn Trust, Dept Immunol, Great Ormond St Hosp, London WC1N 3JH, England

[5] NHS Fdn Trust, Dept Radiol, Great Ormond St Hosp Children, London WC1N 3JH, England

[6] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA

[7] UCL Great Ormond St Inst Child Hlth, Genet & Genom Med, London WC1N 1EH, England

[8] NHS Fdn Trust, Dept Histopathol, Great Ormond St Hosp Children, London WC1N 3JH, England

[9] NHS Fdn Trust, Dept Neurosci, Great Ormond St Hosp, London WC1N 3JH, England

[10] Queens Univ Belfast, Mol Pathol Programme, Ctr Canc Res & Cell Biol, Belfast, Antrim, North Ireland

[11] Belfast Hlth & Social Care Trust, Tissue Pathol, Belfast City Hosp, Lisburn Rd, Belfast, Antrim, North Ireland

[12] Nottingham Univ Hosp NHS Trust, Queens Med Ctr, Nottingham NG7 2UH, England

[13] UCL, UCL Genet Inst, London WC1E 6BT, England

[14] UCL Great Ormond St Inst Child Hlth, Mol & Cellular Immunol Sect, London WC1N 1EH, England

[15] UCL Great Ormond St Inst Child Hlth, Dev Biol & Canc Programme, London WC1N 1EH, England

[16] NHS Fdn Trust, Great Ormond St Hosp Children, Mol & Cellular Immunol, London WC1N 3JH, England

[17] UCL Great Ormond St Inst Child Hlth, London WC1N 1EH, England

来源：

ACTA NEUROPATHOLOGICA | 2017年 / 133卷 / 01期

关键词：

BIASED HYPERMUTATION; MEASLES; STRAIN; MIXTURE; GENE; TOOL;

D O I：

10.1007/s00401-016-1629-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Routine childhood vaccination against measles, mumps and rubella has virtually abolished virus-related morbidity and mortality. Notwithstanding this, we describe here devastating neurological complications associated with the detection of live-attenuated mumps virus Jeryl Lynn (MuV(JL5)) in the brain of a child who had undergone successful allogeneic transplantation for severe combined immunodeficiency (SCID). This is the first confirmed report of MuV(JL5) associated with chronic encephalitis and highlights the need to exclude immunodeficient individuals from immunisation with live-attenuated vaccines. The diagnosis was only possible by deep sequencing of the brain biopsy. Sequence comparison of the vaccine batch to the MuV(JL5) isolated from brain identified biased hypermutation, particularly in the matrix gene, similar to those found in measles from cases of SSPE. The findings provide unique insights into the pathogenesis of paramyxovirus brain infections.

引用

页码：139 / 147

页数：9

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