Prognostic and predictive value of tumor in early breast cancer

被引：51
|
作者：
Criscitiello, Carmen [1 ]
Esposito, Angela [1 ]
Trapani, Dario [1 ]
Curigliano, Giuseppe [1 ]
机构：
[1] Ist Europeo Oncol, Via Ripamonti 435, I-20141 Milan, Italy
来源：
CANCER TREATMENT REVIEWS | 2016年 / 50卷
关键词：
Breast cancer; Tumor infiltrating lymphocytes; Biomarker; INFILTRATING LYMPHOCYTES; NEOADJUVANT CHEMOTHERAPY; FREE SURVIVAL; TRASTUZUMAB; TRIAL;
D O I：
10.1016/j.ctrv.2016.09.019
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It is well recognized that the immune system plays an essential role in tumor defense. The presence of tumor-infiltrating lymphocytes reflects an individual immunological response. In early breast cancer, the presence of TILs is associated with a more favorable outcome and response to therapy. In this review, we describe how TILs are assessed. Also, we discuss their role as prognostic and predictive biomarker in the neoadjuvant and adjuvant settings as well as in residual disease. Moreover, we discuss the possible implementation of TILs in daily clinical practice as well as in future clinical trials in order to fine tune prognosis and improve treatments. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：205 / 207
页数：3
相关论文
共 50 条
  • [21] Predictive and Prognostic Value of Selected MicroRNAs in Luminal Breast Cancer
    Amorim, Maria
    Lobo, Joao
    Fontes-Sousa, Mario
    Estevao-Pereira, Helena
    Salta, Sofia
    Lopes, Paula
    Coimbra, Nuno
    Antunes, Luis
    de Souse, Susana Palma
    Henrique, Rui
    Jeronimo, Carmen
    FRONTIERS IN GENETICS, 2019, 10
  • [22] Prognostic and predictive value of enzymes of the sphingolipid metabolism in breast cancer
    Ruckhaeberle, E.
    Rody, A.
    Gaetje, R.
    Engels, K.
    Holtrich, U.
    Karn, T.
    Kaufmann, M.
    CANCER RESEARCH, 2009, 69 (02) : 352S - 352S
  • [23] Prognostic and predictive value of thymidine labelling index in breast cancer
    Amadori, D
    Silvestrini, R
    BREAST CANCER RESEARCH AND TREATMENT, 1998, 51 (03) : 267 - 281
  • [24] Predictive and prognostic value of prognostic nutritional index for locally advanced breast cancer
    Wang, Yaohui
    Battseren, Bayarmaa
    Yin, Wenjin
    Lin, Yanping
    Zhou, Liheng
    Yang, Fan
    Wang, Yan
    Sun, Lu
    Lu, Jinsong
    GLAND SURGERY, 2019, 8 (06) : 618 - 626
  • [25] Prognostic and Predictive Role of Circulating Tumor Cells in Breast Cancer
    Mego M.
    Reuben J.M.
    Current Breast Cancer Reports, 2014, 6 (4) : 251 - 259
  • [26] PROGNOSTIC VALUE OF AGE FOR PATIENTS WITH EARLY BREAST CANCER
    Kolyadina, I. V.
    Poddubnaya, I. V.
    de Velde, C. J. H. Van
    Kuppen, P. J. K.
    Dekker-Ensink, N. G.
    de Kruijf, E.
    Sajet, A.
    Liefers, G. J.
    Bastiaannet, E.
    Frank, G. A.
    Komov, D. V.
    Ozhereliev, A. S.
    Karseladze, Al.
    Ermilova, V. D.
    Vishnevskaya, Y. V.
    Makarenko, N. P.
    Teterin, Ka.
    Banov, S. M.
    SOVREMENNYE TEHNOLOGII V MEDICINE, 2012, (03) : 31 - 34
  • [27] Prognostic and predictive value of circulating tumor DNA during neoadjuvant chemotherapy for triple negative breast cancer
    Luca Cavallone
    Adriana Aguilar-Mahecha
    Josiane Lafleur
    Susie Brousse
    Mohammed Aldamry
    Talia Roseshter
    Cathy Lan
    Najmeh Alirezaie
    Eric Bareke
    Jacek Majewski
    Cristiano Ferrario
    Saima Hassan
    Federico Discepola
    Carole Seguin
    Catalin Mihalcioiu
    Elizabeth A. Marcus
    André Robidoux
    Josée-Anne Roy
    Manuela Pelmus
    Mark Basik
    Scientific Reports, 10
  • [28] Circulating Tumor DNA Is a Variant of Liquid Biopsy with Predictive and Prognostic Clinical Value in Breast Cancer Patients
    Zavarykina, Tatiana M.
    Lomskova, Polina K.
    Pronina, Irina V.
    Khokhlova, Svetlana V.
    Stenina, Marina B.
    Sukhikh, Gennady T.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (23)
  • [29] Prognostic and predictive value of circulating tumor DNA during neoadjuvant chemotherapy for triple negative breast cancer
    Cavallone, Luca
    Aguilar-Mahecha, Adriana
    Lafleur, Josiane
    Brousse, Susie
    Aldamry, Mohammed
    Roseshter, Talia
    Lan, Cathy
    Alirezaie, Najmeh
    Bareke, Eric
    Majewski, Jacek
    Ferrario, Cristiano
    Hassan, Saima
    Discepola, Federico
    Seguin, Carole
    Mihalcioiu, Catalin
    Marcus, Elizabeth A.
    Robidoux, Andre
    Roy, Josee-Anne
    Pelmus, Manuela
    Basik, Mark
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [30] Predictive and prognostic value of tumor-infiltrating lymphocytes in breast cancer treated with neoadjuvant chemotherapy.
    Matsumoto, Akiko
    Jinno, Hiromitsu
    Hiraiwa, Kunihiko
    Nakamura, Tetsuya
    Saito, Junichi
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (28)
12345