Discovery of NMDA Glycine Site Inhibitors from the Chemical Universe Database GDB

被引：34

作者：

Nguyen, Kong Thong ^{[1
]}

Syed, Salahuddin ^{[1
]}

Urwyler, Stephan ^{[2
]}

Bertrand, Sonia ^{[3
]}

Bertrand, Daniel ^{[3
]}

Reymond, Jean-Louis ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

[2] Novortis Inst BioMed Res, Neurosci, CH-4002 Basel, Switzerland

[3] Univ Geneva, Dept Neurosci, Fac Med, CH-1211 Geneva 4, Switzerland

来源：

CHEMMEDCHEM | 2008年 / 3卷 / 10期

基金：

瑞士国家科学基金会;

关键词：

computer chemistry; inhibitors; receptors; virtual screening;

D O I：

10.1002/cmdc.200800198

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The first virtual screening search through the entire chemical space of small organic ligands has identified promising ligands as inhibitors of the N-methyl-D-aspartic acid (NMDA) receptor glycine site. This receptor is an important drug target implicated in synaptic plasticity, neuronal development, learning, and memory. Inhibiting the NMDA receptor may help prevent neuronal cell death caused byglutam ate excitotoxicity in acute and chronic neurodegenerative disorders. (Figure Presented). © 2008 Wiley-VCH Verlag GmbH& Co. KGaA.

引用

页码：1520 / 1524

页数：5

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