Discovery of NMDA Glycine Site Inhibitors from the Chemical Universe Database GDB

被引：34
|
作者：
Nguyen, Kong Thong [1 ]
Syed, Salahuddin [1 ]
Urwyler, Stephan [2 ]
Bertrand, Sonia [3 ]
Bertrand, Daniel [3 ]
Reymond, Jean-Louis [1 ]
机构：
[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland
[2] Novortis Inst BioMed Res, Neurosci, CH-4002 Basel, Switzerland
[3] Univ Geneva, Dept Neurosci, Fac Med, CH-1211 Geneva 4, Switzerland
来源：
CHEMMEDCHEM | 2008年 / 3卷 / 10期
基金：
瑞士国家科学基金会;
关键词：
computer chemistry; inhibitors; receptors; virtual screening;
D O I：
10.1002/cmdc.200800198
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The first virtual screening search through the entire chemical space of small organic ligands has identified promising ligands as inhibitors of the N-methyl-D-aspartic acid (NMDA) receptor glycine site. This receptor is an important drug target implicated in synaptic plasticity, neuronal development, learning, and memory. Inhibiting the NMDA receptor may help prevent neuronal cell death caused byglutam ate excitotoxicity in acute and chronic neurodegenerative disorders. (Figure Presented). © 2008 Wiley-VCH Verlag GmbH& Co. KGaA.
引用
收藏
页码：1520 / 1524
页数：5
相关论文
共 50 条
  • [1] 3-(Aminomethyl)piperazine-2,5-dione as a novel NMDA glycine site inhibitor from the chemical universe database GDB
    Nguyen, Kong Thong
    Luethi, Erika
    Syed, Salahuddin
    Urwyler, Stephan
    Bertrand, Sonia
    Bertrand, Daniel
    Reymond, Jean-Louis
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (14) : 3832 - 3835
  • [2] Mining the chemical universe database GDB-17 for drug discovery
    Reymond, Jean-Louis
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [3] Discovery of nicotinic acetylcholine receptor ligands in the chemical universe database GDB-13
    Blum, L. C.
    van Deursen, R.
    Buergi, J.
    Reymond, J. -L.
    Maver, M.
    Bertrand, S.
    Bertrand, D.
    BIOCHEMICAL PHARMACOLOGY, 2011, 82 (08) : 1027 - 1027
  • [4] Discovery of α7-Nicotinic Receptor Ligands by Virtual Screening of the Chemical Universe Database GDB-13
    Blum, Lorenz C.
    van Deursen, Ruud
    Bertrand, Sonia
    Mayer, Milena
    Buergi, Justus J.
    Bertrand, Daniel
    Reymond, Jean-Louis
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2011, 51 (12) : 3105 - 3112
  • [5] Visualization and Virtual Screening of the Chemical Universe Database GDB-17
    Ruddigkeit, Lars
    Blum, Lorenz C.
    Reymond, Jean-Louis
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2013, 53 (01) : 56 - 65
  • [6] Visualisation and subsets of the chemical universe database GDB-13 for virtual screening
    Lorenz C. Blum
    Ruud van Deursen
    Jean-Louis Reymond
    Journal of Computer-Aided Molecular Design, 2011, 25 : 637 - 647
  • [7] Visualisation and subsets of the chemical universe database GDB-13 for virtual screening
    Blum, Lorenz C.
    van Deursen, Ruud
    Reymond, Jean-Louis
    JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2011, 25 (07) : 637 - 647
  • [8] Exploring α7-Nicotinic Receptor Ligand Diversity by Scaffold Enumeration from the Chemical Universe Database GDB
    Garcia-Delgado, Noemi
    Bertrand, Sonia
    Nguyen, Kong T.
    van Deursen, Ruud
    Bertrand, Daniel
    Reymond, Jean-Louis
    ACS MEDICINAL CHEMISTRY LETTERS, 2010, 1 (08): : 422 - 426
  • [9] Enumeration of 166 Billion Organic Small Molecules in the Chemical Universe Database GDB-17
    Ruddigkeit, Lars
    van Deursen, Ruud
    Blum, Lorenz C.
    Reymond, Jean-Louis
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2012, 52 (11) : 2864 - 2875
  • [10] Identification of Selective Norbornane-Type Aspartate Analogue Inhibitors of the Glutamate Transporter 1 (GLT-1) from the Chemical Universe Generated Database (GDB)
    Luethi, Erika
    Nguyen, Kong T.
    Buerzle, Marc
    Blum, Lorenz C.
    Suzuki, Yoshiro
    Hediger, Matthias
    Reymond, Jean-Louis
    JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (19) : 7236 - 7250
12345