Listeria monocytogenes infection in mice treated with pentoxifylline

被引：0
|
作者：
Brzychcy, M
Klink, M
Tchorzewski, H
Rudnicka, W
机构：
[1] UNIV LODZ,DEPT INFECT BIOL,PL-90237 LODZ,POLAND
[2] POLISH ACAD SCI,CTR MICROBIOL & VIROL,PL-93251 LODZ,POLAND
来源：
ZENTRALBLATT FUR BAKTERIOLOGIE-INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY VIROLOGY PARASITOLOGY AND INFECTIOUS DISEASES | 1997年 / 285卷 / 04期
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D O I：
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中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The course of L. monocytogenes infection was followed in mice treated with pentoxifylline (POF), a known inhibitor of endogenous tumor necrosis factor (TNF) formation. Administration of POF caused a delay in L. monocytogenes elimination which was probably related to a reduction the listericidal activity of macrophages and to an attenuation of delayed type hypersensitivity (DTH) to Listeria antigens. In spite of this, some POP-treated mice were protected from lethal effects of virulent L. monocytogenes bacteria.
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页码：491 / 500
页数：10
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