Analgesic effects of methanolic extract of Capparis zeylanica Linn. roots

被引：0
|
作者：
Upaganlawar, A. B. [1 ]
Chopade, V. V. [1 ]
Ghule, B. V. [1 ]
Yeole, P. G. [1 ]
机构：
[1] Inst Pharmaceut Educ & Res, Wardha 442001, MS, India
来源：
PHARMACOGNOSY MAGAZINE | 2008年 / 4卷 / 13期
关键词：
Capparis zeylanica; Analgesic activity; Writhing; Hot plate; Tail immersion tests;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The present study was aimed to investigate the analgesic effects of the methanolic extract of Capparis zeylanica Linn. (MECZ) roots in rats and mice. The MECZ (250-500 mg/kg; p.o.) was evaluated for its analgesic activity by employing acetic acid-induced writhing test, hot plate test and tail immersion tests i.e. in hot and cold water. MECZ (250-500 mg/kg; p.o.) showed significant (P<0.01) reduction in the number of writhing induced by acetic acid, increased reaction time in hot plate test and elevated pain threshold in hot and cold water tests. MECZ exhibited the dose-dependent analgesic effects. In addition, the acute toxicity studies revealed that MECZ has good margin of safety and did not show the lethal effects on the animals up to the doses of 4 g/kg.
引用
收藏
页码：112 / 114
页数：3
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