Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms

被引：69

作者：

Hoque, Jiaul ^{[1
]}

Konai, Mohini M. ^{[1
]}

Samaddar, Sandip ^{[1
]}

Gonuguntala, Spandhana ^{[1
]}

Manjunath, Goutham B. ^{[1
]}

Ghosh, Chandradhish ^{[1
]}

Haldar, Jayanta ^{[1
]}

机构：

[1] Jawaharlal Nehru Ctr Adv Sci Res, New Chem Unit, Chem Biol & Med Chem Lab, Jakkur 560064, Bengaluru, India

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 71期

关键词：

PSEUDOMONAS-AERUGINOSA; ANTIBACTERIAL PEPTIDES; PERSISTENT INFECTIONS; PEPTOID MIMICS; MEMBRANE; LIPOPEPTIDES; MECHANISM; POTENT; OLIGOMERS; POLYMERS;

D O I：

10.1039/c5cc05159b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rationally designed amphiphilic small molecules selectively kill drug-sensitive and drug-resistant bacteria over mammalian cells. The small molecules disperse preformed biofilms and reduce viable bacterial count in the biofilms. Moreover, this class of membran-active molecules disarms the development of bacterial resistance.

引用

页码：13670 / 13673

页数：4

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