Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum

被引：24
|
作者：
D'Este, L
Scontrini, A
Casini, A
Pontieri, FE
Renda, TG
机构：
[1] Fac Med 1, Inst Human Anat, I-00161 Rome, Italy
[2] Univ Roma La Sapienza, Fac Med 2, Dept Neurosci, I-00161 Rome, Italy
来源：
BRAIN RESEARCH | 2002年 / 933卷 / 02期
关键词：
c-Fos oncoprotein; heroin; sensitization; caudate-putamen; nucleus accumbens shell; immunohistochemistry;
D O I：
10.1016/S0006-8993(02)02312-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell. whereas the sa-me dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：144 / 149
页数：6
相关论文
共 50 条
  • [21] Gabapentin completely attenuated the acute morphine induced c-Fos expression in the rat striatum
    J. A. Kazi
    C. F. Gee
    Journal of Molecular Neuroscience, 2007, 32 : 47 - 52
  • [22] Involvement of nitric oxide in morphine-induced c-Fos expression in the rat striatum
    Harlan, RE
    Webber, DS
    Garcia, MM
    BRAIN RESEARCH BULLETIN, 2001, 54 (02) : 207 - 212
  • [23] RETRACTED ARTICLE: The pattern of c-Fos immunoreactivity in the hindbrain of the rat following stomach distension
    M. Sabbatini
    C. Molinari
    E. Grossini
    D. A. S. G. Mary
    G. Vacca
    M. Cannas
    Experimental Brain Research, 2004, 157 : 315 - 323
  • [24] c-Fos basal immunoreactivity decreases in rat spinal cord during normal ageing
    Kim, JM
    Lee, KW
    Chung, YH
    Shin, CM
    Baik, SH
    Cha, CI
    NEUROREPORT, 1999, 10 (03) : 585 - 588
  • [25] The effect of normovolemic hemodilution on c-Fos protein immunoreactivity in the postischemic rat brain cortex
    Miroslava, N
    Burda, J
    Danielisová, V
    Marsala, J
    INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2005, 115 (04) : 523 - 536
  • [26] Retraction Note: The pattern of c-Fos immunoreactivity in the hindbrain of the rat following stomach distension
    M. Sabbatini
    C. Molinari
    E. Grossini
    D. A. S. G. Mary
    G. Vacca
    M. Cannas
    Experimental Brain Research, 2024, 242 : 987 - 987
  • [27] FORSKOLIN INCREASES PHOSPHORYLATED-CREB AND FOS IMMUNOREACTIVITY IN RAT STRIATUM
    SIMPSON, JN
    MCGINTY, JF
    NEUROREPORT, 1994, 5 (10) : 1213 - 1216
  • [28] Glutamatergic regulation of haloperidol-induced c-fos expression in the rat striatum and nucleus accumbens
    Hussain, N
    Flumerfelt, BA
    Rajakumar, N
    NEUROSCIENCE, 2001, 102 (02) : 391 - 399
  • [29] OXYTOCIN NEURONS IN THE RAT HYPOTHALAMUS EXHIBIT C-FOS IMMUNOREACTIVITY UPON OSMOTIC-STRESS
    GIOVANNELLI, L
    SHIROMANI, PJ
    JIRIKOWSKI, GF
    BLOOM, FE
    BRAIN RESEARCH, 1990, 531 (1-2) : 299 - 303
  • [30] MUTANT SPASTIC RATS BUT NOT CONTROLS EXPRESS C-FOS IN THE STRIATUM
    BLOCK, F
    DACRUZ, L
    SONTAG, KH
    OSBORNE, NN
    EUROPEAN JOURNAL OF NEUROSCIENCE, 1992, : 200 - 200
12345