The biology of Hodgkin's lymphoma

被引：473

作者：

Kueppers, Ralf ^{[1
]}

机构：

[1] Univ Duisburg Essen, Sch Med, Inst Cell Biol Tumour Res, D-45122 Essen, Germany

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 01期

关键词：

REED-STERNBERG CELLS; EPSTEIN-BARR-VIRUS; CENTER B-CELLS; ANAPLASTIC LARGE-CELL; FACTOR-KAPPA-B; PERIPHERAL-BLOOD LYMPHOCYTES; RECEPTOR TYROSINE KINASES; FUNCTIONAL CD30 LIGAND; REGULATORY T-CELLS; MEMBRANE-PROTEIN;

D O I：

10.1038/nrc2542

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hodgkin's lymphoma was first described in 1832. The aetiology of this lymphoma, however, remained enigmatic for along time. Only within the past 10 years has the B-cell nature of the pathognomonic Hodgkin and Reed-Sternberg (HRS) cells been revealed, along with several recurrent genetic lesions. The pathogenetic role for Epstein-Barr virus infection has also been substantiated. HRS cells in classical Hodgkin's lymphoma have several characteristics that are unusual for lymphoid tumour cells, and the Hodgkin's lymphoma microenvironment is dominated by an extensive mixed, potentially inflammatory cellular infiltrate. Understanding the contribution of all of these changes to the pathogenesis of this disease is essential for the development of novel therapies.

引用

页码：15 / 27

页数：13

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