Spectrophotometric Determination of Quinolone Antibiotics by an Association Complex Formation with Aluminum(III) and Erythrosin

被引：9

作者：

Yamaguchi, Takako ^{[1
]}

Nakao, Masahiro ^{[1
]}

Nakahara, Ryosuke ^{[1
]}

Njishioka, Yuka ^{[1
]}

Ikeia, Chiho ^{[1
]}

Fujia, Yoshikazu ^{[1
]}

机构：

[1] Osaka Univ Pharmaceut Sci, Osaka 5691094, Japan

来源：

ANALYTICAL SCIENCES | 2009年 / 25卷 / 01期

关键词：

PERFORMANCE LIQUID-CHROMATOGRAPHY; OFLOXACIN; DNA; PHARMACEUTICALS; HYDROCHLORIDE; DERIVATIVES; EQUILIBRIA; PROTEIN; GYRASE; ION;

D O I：

10.2116/analsci.25.125

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple and sensitive spectrophotometric method for the determination of quinolone antibiotics was established based on an association complex formation with aluminum(III) and erythrosin. In the determination of ofloxacin as a quinolone antibiotic, Beer's law is obeyed in the range of 0.1 - 3.2 mu g ml(-1), with an effective molar absorptivity at 555 nm and the relative standard deviation being 1.2 x 10(5) L mol(-1) cm(-1) and 0.9% (n = 6). This method was Successfully applied to the assay of quinolone antibiotics in pharmaceutical preparations.

引用

页码：125 / 128

页数：4

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