Anti-obesity and hypolipidemic effect of water extract from Pleurotus citrinopileatus in C57BL/6J mice

Obesity has become one of the most important health problems worldwide requiring urgent need for efficient control. Pleurotuscitrinopileatus (P.citrinopileatus)a type of edible mushroom with abundant bioactive moleculesis a promising source for achieving this goal. In the present study, we evaluated the anti-obesity and hypolipidemic effect of P.citrinopileatus water extract (PWE) using a series of biochemical assays in randomized high-fat diet-induced obese (DIO) C57BL/6J mice, which were gavaged daily with low or high levels of PWE (400 or 800mg/kg of body weight, respectively) in addition to high-fat diet for 12weeks. Results showed that PWE significantly reduced the weight gain, fat accumulation, and food intake of DIO mice within 12weeks. PWE also decreased the serum triglycerides, cholesterol and low-density lipoprotein, aspartate transaminase, nonesterified fatty acid, and creatinine, but increased high-density lipoprotein. Additionally, PWE improved the glucose tolerance of mice fed with high fat. From above, we conclude that PWE has great potential as functional foods for management of obesity and/or associated metabolic disorders.