Long-Term Results of the Head and Neck Squamous Cell Carcinomas Treatment Depending on the Therapy

The frequency of occurrence of relapses and delayed regional metastases in the lymph nodes in the patients with head and neck tumors depending on various combinations of operative and radiotherapy are estimated in the work. It is shown that tumor progression occurs more often in the case of radiotherapy as the only method of treatment. The parameters of general, disease-free and non-metastatic survival were evaluated. In the evaluation of the survival rate, a decrease in disease-free survival in head and neck squamous cell carcinomas patients with radiotherapy treatment was observed. Disease-free survival is better in the patients receiving surgical treatment than in the patients with radiotherapy (log rank test p = 0.043), as well as above disease-free survival in the patients with combination of neoadjuvant radiotherapy and surgery vs neoadjuvant radiotherapy alone (p = 0.042). It is also shown that human papillomavirus is not a risk factor for tumor progression and does not affect the course of the disease.