The first total synthesis of natural grenadamide

被引：15
|
作者：
Avery, TD [1 ]
Culbert, JA [1 ]
Taylor, DK [1 ]
机构：
[1] Univ Adelaide, Dept Chem, Adelaide, SA 5005, Australia
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 02期
关键词：
D O I：
10.1039/b513774h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise, high yielding route to the naturally occurring enantiomer of grenadamide utilizing a 3,6-disubstituted 1,2-dioxine starting material is presented. The route allows for ease in synthesizing grenadamide derivatives varying at cyclopropyl carbons 2 and 3, with access to both enantiomers. Evidence for phosphorus-assisted deprotonation of 1,2-dioxines is also discussed.
引用
收藏
页码：323 / 330
页数：8
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