The Role of Micro RNA and Long-Non-Coding RNA in Osteoporosis

被引:72
|
作者
Ko, Nai-Yu [1 ]
Chen, Li-Ru [1 ,2 ]
Chen, Kuo-Hu [3 ,4 ]
机构
[1] Mackay Mem Hosp, Dept Phys Med & Rehabil, Taipei 104, Taiwan
[2] Natl Chiao Tung Univ, Dept Mech Engn, Hsinchu 300, Taiwan
[3] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Obstet & Gynecol, Taipei 231, Taiwan
[4] Tzu Chi Univ, Sch Med, Hualien 970, Taiwan
关键词
osteoporosis; micro RNA; miRNA; long-non-coding RNA; lncRNA; MESENCHYMAL STEM-CELLS; OSTEOGENIC DIFFERENTIATION; POSTMENOPAUSAL OSTEOPOROSIS; ALLEVIATES OSTEOPOROSIS; CIRCULATING MIRNAS; PROMOTES; PROGRESSION; EXPRESSION; OSTEOCLASTS; RATS;
D O I
10.3390/ijms21144886
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Osteoporosis is a major concern worldwide and can be attributed to an imbalance between osteoblastic bone formation and osteoclastic bone resorption due to the natural aging process. Heritable factors account for 60-80% of optimal bone mineralization; however, the finer details of pathogenesis remain to be elucidated. Micro RNA (miRNA) and long-non-coding RNA (lncRNA) are two targets that have recently come into the spotlight due to their ability to control gene expression at the post-transcriptional level and provide epigenetic modification. miRNAs are a class of non-coding RNAs that are approximately 18-25 nucleotides long. It is thought that up to 60% of human protein-coding genes may be regulated by miRNAs. They have been found to regulate gene expression that controls osteoblast-dependent bone formation and osteoclast-related bone remodeling. lncRNAs are highly structured RNA transcripts longer than 200 nucleotides that do not translate into proteins. They have very complex secondary and tertiary structures and the same degradation processes as messenger RNAs. The fact that they have a rapid turnover is due to their sponge function in binding the miRNAs that lead to a degradation of the lncRNA itself. They can act as signaling, decoy, and framework molecules, or as primers. Current evidence suggests that lncRNAs can act as chromatin and transcriptional as well as post-transcriptional regulators. With regards to osteoporosis, lncRNA is thought to be involved in the proliferation, apoptosis, and inflammatory response of the bone. This review, which is based on a systematic appraisal of the current literature, provides current molecular and genetic opinions on the roles of miRNAs and lncRNAs in osteoporosis. Further research into the epigenetic modification and the regulatory roles of these molecules will bring us closer to potential disease-modifying treatment for osteoporosis. However, more issues regarding the detailed actions of miRNAs and lncRNAs in osteoporosis remain unknown and controversial and warrant future investigation.
引用
收藏
页码:1 / 18
页数:18
相关论文
共 50 条
  • [31] THE ROLE FOR LONG NON-CODING RNA IN COLORECTAL CANCER METASTASIS
    Soroosh, Artin
    Padua, David
    Videlock, Elizabeth J.
    Bui, Diane
    Patel, Ami
    Pothoulakis, Charalabos
    Rankin, Carl R.
    GASTROENTEROLOGY, 2020, 158 (06) : S289 - S290
  • [32] Role of microRNA and Long Non-Coding RNA in Hepatocellular Carcinoma
    Gupta, Meenakshi
    Chandan, Kumari
    Sarwat, Maryam
    CURRENT PHARMACEUTICAL DESIGN, 2020, 26 (04) : 415 - 428
  • [33] The Long-Non-Coding RNA Snhg12 Is Dysregulated in Heart Failure and Controls Endothelial Cell and Cardiomyocyte Function
    Aslan, Galip S.
    Drachsler, Moritz
    Meder, Benjamin
    Boeckel, Jes N.
    Katus, Hugo A.
    Bar, Christian
    Thum, Thomas
    Zeiher, Andreas M.
    Lucas, Tina
    Manavski, Yosif
    Dimmeler, Stefanie
    CIRCULATION, 2018, 138
  • [34] The long-non-coding RNA Snhg1 is essencial for memory CD8 T cell establishment
    Li, B.
    Bai, Q.
    Wang, P.
    Li, Z.
    Hu, L.
    Zhou, X.
    Wu, Y.
    Ye, L.
    Zhang, Y.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 242 - 242
  • [35] Long-Non-Coding RNA HypERrlnc Regulates Human Pericyte Function by Modulation of the Endoplasmic Reticulum-Stress Cell Response
    Bischoff, Florian
    Werner, Astrid
    Boeckel, Jes-Niels
    Demolli, Shemsi
    Michalik, Katharina
    Meder, Benjamin
    Katus, Hugo A.
    Haas, Jan
    Chen, Wei
    John, David
    Uchida, Shizuka
    Zeiher, Andreas M.
    Dimmeler, Stefanie
    Zehendner, Christoph M.
    CIRCULATION, 2016, 134
  • [36] Long-non-coding RNA AK001058: A genetic biomarker in cisplatin sensitivity of non-small-cell lung carcinoma
    Deng, Yongjun
    Li, Huimin
    Liu, Chao
    Xia, Xiuqiong
    Lv, Yanhua
    Zhang, Dandan
    Liang, Jianping
    CELLULAR AND MOLECULAR BIOLOGY, 2023, 69 (14) : 217 - 220
  • [37] Long Non-Coding RNA in Cancer
    Hauptman, Nina
    Glavac, Damjan
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (03) : 4655 - 4669
  • [38] Long Non Coding RNA Biology Foreword
    Steinmetz, Lars M.
    Pelechano, Vicent
    LONG NON CODING RNA BIOLOGY, 2017, 1008 : V - VI
  • [39] Long non-coding RNA and cancer
    Akiyama, Tetsu
    Nishida, Naohiro
    CANCER SCIENCE, 2018, 109 : 1101 - 1101
  • [40] Long Non Coding RNA Biology Preface
    Rao, M. R. S.
    LONG NON CODING RNA BIOLOGY, 2017, 1008 : VII - IX