Profiling oncogenic extra-chromosomal DNA in cancer

被引：0
|
作者：
Hung, King L. [1 ]
Chang, Howard Y. [1 ]
机构：
[1] Stanford Univ, Stanford, CA 94305 USA
来源：
NATURE GENETICS | 2022年 / 54卷 / 11期
关键词：
D O I：
10.1038/s41588-022-01193-x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Cancer cells frequently amplify oncogenes on DNA molecules outside of chromosomes - extrachromosomal DNA. A technique adapted for isolation of extrachromosomal DNA, termed CRISPR-CATCH, enables analyses of its genetic and epigenetic compositions, which provides insights into its origin, structural diversity and mechanism of oncogene activation in cancer.
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收藏
页码：1591 / 1592
页数：2
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