Photoluminescent DNA binding and cytotoxic activity of a platinum(II) complex bearing a tetradentate β-diketiminate ligand

被引：26
|
作者：
Hope, Jennifer M. [1 ]
Wilson, Justin J. [1 ]
Lippard, Stephen J. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
DALTON TRANSACTIONS | 2013年 / 42卷 / 09期
关键词：
LIGHT-SWITCH; METALLOINTERCALATION REAGENTS; TERPYRIDINE COMPLEXES; AQUEOUS-SOLUTIONS; INTERCALATION; AGGREGATION; SPECTROSCOPY; REACTIVITY; PORPHYRIN; STACKING;
D O I：
10.1039/c2dt32462h
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A platinum(II) complex of a monoanionic, tetradentate beta-diketiminate (BDI) ligand with pendant quinoline arms, (BDIH)-H-QQ, is reported. The complex, [Pt(BDIQQ)]Cl, is emissive in DMSO, but non-emissive in aqueous buffer. Upon binding DNA in buffer, however, a 150-fold turn-on in emission intensity occurs. Dynamic light scattering and H-1 NMR spectroscopy indicate that [Pt(BDIQQ)]Cl forms non-emissive aggregates in aqueous solution; DNA-binding disperses the aggregates leading to the large emission turn-on response. The cytotoxic activity of the complex, measured in two cancer cell lines, is comparable to or better than that of the established anticancer drug cisplatin.
引用
收藏
页码：3176 / 3180
页数：5
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