Interaction between serotonin transporter and dopamine D2/D3 receptor radioligand measures is associated with harm avoidant symptoms in anorexia and bulimia nervosa

被引:50
|
作者
Bailer, Ursula F. [1 ,2 ]
Frank, Guido K. [3 ,4 ]
Price, Julie C. [5 ]
Meltzer, Carolyn C. [5 ,6 ,7 ,8 ,9 ,10 ]
Becker, Carl [5 ]
Mathis, Chester A. [5 ]
Wagner, Angela [1 ]
Barbarich-Marsteller, Nicole C. [11 ]
Bloss, Cinnamon S. [12 ,13 ]
Putnam, Karen [14 ]
Schork, Nicholas J. [15 ,16 ]
Gamst, Anthony [17 ]
Kaye, Walter H. [1 ]
机构
[1] Univ Calif San Diego, UCSD Dept Psychiat, La Jolla, CA 92037 USA
[2] Med Univ Vienna, Dept Psychiat & Psychotherapy, Div Biol Psychiat, Vienna, Austria
[3] Univ Colorado Denver, Childrens Hosp Colorado, Dept Psychiat, Aurora, CO USA
[4] Univ Colorado Denver, Dept Neurosci, Aurora, CO USA
[5] Univ Pittsburgh, Presbyterian Univ Hosp, Sch Med, Dept Radiol, Pittsburgh, PA 15213 USA
[6] Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, Sch Med, Pittsburgh, PA 15213 USA
[7] Emory Sch Med, Dept Radiol, Atlanta, GA USA
[8] Emory Sch Med, Dept Neurol, Atlanta, GA USA
[9] Emory Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA
[10] Univ Pittsburgh Sch Med, Pittsburgh, PA USA
[11] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA
[12] STSI, Scripps Genom Med, La Jolla, CA USA
[13] Scripps Hlth, La Jolla, CA USA
[14] Univ Cincinnati, Dept Environm Hlth, Sch Med, Div Epidemiol & Biostat, Cincinnati, OH USA
[15] Scripps Res Inst, La Jolla, CA 92037 USA
[16] STSI, La Jolla, CA USA
[17] Univ Calif San Diego, Dept Biostat & Bioinformat, La Jolla, CA 92037 USA
基金
奥地利科学基金会;
关键词
Anorexia nervosa; Bulimia nervosa; Positron emission tomography; Dopamine; Serotonin; Harm avoidance; POSITRON-EMISSION-TOMOGRAPHY; LONG-TERM STABILITY; BRAIN-SEROTONIN; IN-VIVO; PERSONALITY-TRAITS; EATING-DISORDERS; CEREBROSPINAL-FLUID; C-11; RACLOPRIDE; D-2; RECEPTORS; BINDING;
D O I
10.1016/j.pscychresns.2012.06.010
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Individuals with anorexia nervosa (AN) and bulimia nervosa (BN) have alterations of measures of serotonin (5-HT) and dopamine (DA) function, which persist after long-term recovery and are associated with elevated harm avoidance (HA), a measure of anxiety and behavioral inhibition. Based on theories that 5-HT is an aversive motivational system that may oppose a DA-related appetitive system, we explored interactions of positron emission tomography (PET) radioligand measures that reflect portions of these systems. Twenty-seven individuals recovered (REC) from eating disorders (EDs) (7 AN-BN, 11 AN, 9 BN) and nine control women (CW) were analyzed for correlations between [C-11]McN5652 and [C-11]raclopride binding. There was a significant positive correlation between [C-11]McN5652 binding potential (BPnon displaceable(ND)) and [C-11]Raclopride BPND for the dorsal caudate, antero-ventral striatum (AVS), middle caudate, and ventral and dorsal putamen. No significant correlations were found in CW. [C-11]Raclopride BPND, but not [C-11]McN5652 BPND, was significantly related to HA in REC EDs. A linear regression analysis showed that the interaction between [C-11]McN5652 BPND and [C-11]raclopride BPND in the dorsal putamen significantly predicted HA. This is the first study using PET and the radioligands [C-11]McN5652 and [C-11]raclopride to show a direct relationship between 5-HT transporter and striatal DA D2/D3 receptor binding in humans, supporting the possibility that 5-HT and DA interactions contribute to HA behaviors in EDs. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:160 / 168
页数:9
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