Airway epithelial cells produce stem cell factor

被引：32
|
作者：
Wen, LP
Fahrni, JA
Matsui, S
Rosen, GD
机构：
[1] STANFORD UNIV,SCH MED,DIV PULM & CRIT CARE,STANFORD,CA 94305
[2] TOYAMA MED & PHARMACEUT UNIV,DEPT INTERNAL MED 1,SUGITANI,TOYAMA 93001,JAPAN
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1996年 / 1314卷 / 03期
关键词：
epithelial cell; stem cell factor; lung disease;
D O I：
10.1016/S0167-4889(96)00138-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Airway epithelial cells modulate the inflammatory response in asthmatic, allergic and fibrotic lung diseases through the secretion of cytokines that regulate the movement and activation of inflammatory cells. Mast cells play an important role in the pathogenesis of these lung diseases. In this study we report that normal airway epithelial cells express stem cell factor which is a critical mediator of mast cell growth and differentiation and that transforming growth factor-p inhibits secretion of stem cell factor by airway epithelial cells.
引用
收藏
页码：183 / 186
页数：4
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