A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor

被引：41
|
作者：
Baxendale, Ian R. [1 ]
Ley, Steven V. [1 ]
Smith, Christopher D. [1 ]
Tamborini, Lucia [1 ]
Voica, Ana-Florina [1 ]
机构：
[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr ACS, Cambridge CB2 1EW, England
来源：
JOURNAL OF COMBINATORIAL CHEMISTRY | 2008年 / 10卷 / 06期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1021/cc800070a
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A scalable method for the preparation of 4,5-disubstituted thiazoles and imidazoles as distinct regioisomeric products using a modular flow microreactor has been devised. The process makes use of microfluidic reaction chips and packed immobilized-reagent columns to effect bifurcation of the reaction pathway.
引用
收藏
页码：851 / 857
页数：7
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