Generation and Reactions of Vinyllithiums Using Flow Microreactor Systems

被引：0
|
作者：
Aiichiro Nagaki
Yusuke Takahashi
Shigeyuki Yamada
Chika Matsuo
Suguru Haraki
Yuya Moriwaki
Songhee Kim
Jun-ichi Yoshida
机构：
[1] Kyoto University,Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering
来源：
Journal of Flow Chemistry | 2012年 / 2卷
关键词：
flow microreactor; vinyllithium;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Vinyllithiums were effectively generated by bromine-lithium exchange reaction of vinyl bromides with one eq of s-BuLi in a flow microreactor system at 0 °C or 20 °C, although two eq of t-BuLi and much lower temperatures are required for a conventional macro batch reaction. Subsequent reactions with various electrophiles in the flow microreactor system gave the corresponding vinyl compounds in good yields.
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页码：70 / 72
页数：2
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