Completion of the swine genome will simplify the production of swine as a large animal biomedical model

被引：86

作者：

Walters, Eric M. ^{[1
]}

Wolf, Eckhard ^{[2
,3
]}

Whyte, Jeffery J. ^{[1
]}

Mao, Jiude ^{[1
]}

Renner, Simone ^{[2
,3
]}

Nagashima, Hiroshi ^{[5
]}

Kobayashi, Eiji ^{[4
]}

Zhao, Jianguo ^{[1
]}

Wells, Kevin D. ^{[1
]}

Critser, John K. ^{[1
]}

Riley, Lela K. ^{[1
]}

Prather, Randall S. ^{[1
]}

机构：

[1] Univ Missouri, Natl Swine Resource & Res Ctr, Columbia, MO 65211 USA

[2] Dept Vet Sci, D-81377 Munich, Germany

[3] Lab Funct Genome Anal, D-81377 Munich, Germany

[4] Jichi Med Univ, Ctr Dev Adv Technol, Shimotsuke, Tochigi 3290498, Japan

[5] Meiji Univ, Lab Dev Engn, Tama Ku, Kawasaki, Kanagawa 2148571, Japan

来源：

BMC MEDICAL GENOMICS | 2012年 / 5卷

关键词：

Genomic; Pig; Biomedical model; Genetically engineered; Human diseases; BETA-GLOBIN GENE; PORCINE FETAL FIBROBLASTS; PLURIPOTENT STEM-CELLS; ZINC-FINGER NUCLEASES; TRANSGENIC PIGS; CYSTIC-FIBROSIS; KNOCKOUT PIGS; CLONED PIGS; IN-VITRO; ALPHA-1,3-GALACTOSYLTRANSFERASE GENE;

D O I：

10.1186/1755-8794-5-55

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: Anatomic and physiological similarities to the human make swine an excellent large animal model for human health and disease. Methods: Cloning from a modified somatic cell, which can be determined in cells prior to making the animal, is the only method available for the production of targeted modifications in swine. Results: Since some strains of swine are similar in size to humans, technologies that have been developed for swine can be readily adapted to humans and vice versa. Here the importance of swine as a biomedical model, current technologies to produce genetically enhanced swine, current biomedical models, and how the completion of the swine genome will promote swine as a biomedical model are discussed. Conclusions: The completion of the swine genome will enhance the continued use and development of swine as models of human health, syndromes and conditions.

引用

页数：11

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