Synthesis and Antiviral Activity of Adamantylpeptides Against Hepatitis C Virus

被引：2

作者：

Shibnev, V. A. ^{[1
]}

Garaev, T. M. ^{[1
]}

Deryabin, P. G. ^{[1
]}

Finogenova, M. P. ^{[1
]}

Mishin, D. V. ^{[1
]}

机构：

[1] Russian Minist Hlth, NF Gamaleya Fed Sci Res Ctr Epidemiol & Microbiol, DI Ivanovskii Inst Virol, Moscow, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2015年 / 49卷 / 07期

关键词：

adamantane derivatives; peptides; p7; channel; remantadine; hepatitis C; cell cultures; antiviral activity; P7; ION-CHANNEL; PROTEIN; AMANTADINE;

D O I：

10.1007/s11094-015-1302-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New adamantane derivatives with short peptides were synthesized and their in vitro antiviral activity against hepatitis C virus (HCV) was studied. Experiments in pig embryo kidney cells (PEKC) showed that 1-(1-adamantyl)ethylamine derivatives with tri- and tetrapeptide residues were able to suppress HCV replication. Furthermore, this class of compounds was shown to have direct actions on the infective properties of hepatitis C virions (virucidal activity).

引用

页码：449 / 454

页数：6

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