Synthesis and Antiviral Activity of Adamantylpeptides Against Hepatitis C Virus

被引：2
|
作者：
Shibnev, V. A. [1 ]
Garaev, T. M. [1 ]
Deryabin, P. G. [1 ]
Finogenova, M. P. [1 ]
Mishin, D. V. [1 ]
机构：
[1] Russian Minist Hlth, NF Gamaleya Fed Sci Res Ctr Epidemiol & Microbiol, DI Ivanovskii Inst Virol, Moscow, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2015年 / 49卷 / 07期
关键词：
adamantane derivatives; peptides; p7; channel; remantadine; hepatitis C; cell cultures; antiviral activity; P7; ION-CHANNEL; PROTEIN; AMANTADINE;
D O I：
10.1007/s11094-015-1302-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New adamantane derivatives with short peptides were synthesized and their in vitro antiviral activity against hepatitis C virus (HCV) was studied. Experiments in pig embryo kidney cells (PEKC) showed that 1-(1-adamantyl)ethylamine derivatives with tri- and tetrapeptide residues were able to suppress HCV replication. Furthermore, this class of compounds was shown to have direct actions on the infective properties of hepatitis C virions (virucidal activity).
引用
收藏
页码：449 / 454
页数：6
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