Synthesis of Polysubstituted Furans via Copper-Mediated Annulation of Alkyl Ketones with α,β-Unsaturated Carboxylic Acids

被引：67
|
作者：
Yang, Yuzhu [1 ]
Yao, Jinzhong [1 ]
Zhang, Yuhong [1 ,2 ]
机构：
[1] Zhejiang Univ, ZJU NHU United R&D Ctr, Dept Chem, Hangzhou 310027, Peoples R China
[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 13期
关键词：
C-H BONDS; CATALYZED DECARBOXYLATIVE ARYLATION; ALPHA-OXOCARBOXYLIC ACIDS; BENZOIC-ACIDS; VERSATILE CATALYST; OLEFINATION; ACYLATION; FUNCTIONALIZATION; ALKENYLATION; STRATEGY;
D O I：
10.1021/ol400912v
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel copper-mediated annulation of alkyl ketones with alpha,beta-unsaturated carboxylic acids has been accomplished. This reaction provides a facile and regio-defined method for the synthesis of 2,3,5-trisubstituted furans from simple chemical reagents.
引用
收藏
页码：3206 / 3209
页数：4
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