Bronsted Acid-Catalyzed Synthesis of 1,2,5-Trisubstituted Imidazoles via a Multicomponent Reaction of Vinyl Azides with Aromatic Aldehydes and Aromatic Amines

被引：5

作者：

Li, Jiuling ^{[1
]}

Jia, Xinyu ^{[1
]}

Qiu, Ju ^{[1
]}

Wang, Min ^{[1
]}

Chen, Juan ^{[1
]}

Jing, Minghui ^{[1
]}

Xu, Yifu ^{[1
]}

Zheng, Xinhua ^{[1
]}

Dai, Hongmei ^{[1
]}

机构：

[1] Pingdingshan Univ, Henan Engn Res Ctr Funiu Mt Med Resources Utilizat, Sch Med Sci, Pingdingshan 467000, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 21期

关键词：

REGIOSELECTIVE SYNTHESIS; AMIDINES SYNTHESIS; EFFICIENT; COPPER; FUNCTIONALIZATION; CYCLIZATION; PROTOCOL; KETONES; ACCESS;

D O I：

10.1021/acs.joc.2c01624

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient approach to the synthesis of 1,2,5-trisubstituted imidazoles is developed via a multicomponent reaction under metal-free catalysis. Under Bronsted acid catalysis, the desired products can be obtained from readily available vinyl azides, aromatic aldehydes, and aromatic amines without generating any toxic waste. The convenient operations and high functional group compatibility indicate that this approach offers an attractive alternative method for the synthesis of imidazole derivatives.

引用

页码：13945 / 13954

页数：10

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