Homing of stem cells to ischemic myocardium

被引：2
|
作者：
Taghavi, Sharven [1 ,3 ]
George, Jon C. [1 ,2 ]
机构：
[1] Temple Univ, Cardiovasc Res Ctr, Philadelphia, PA USA
[2] Temple Univ, Sch Med, Philadelphia, PA USA
[3] Temple Univ, Hosp Dept Surg, Philadelphia, PA USA
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2013年 / 5卷 / 04期
关键词：
Stem cells; ischemic myocardium; myocardial regeneration; growth factors; myocardial infarction; ENDOTHELIAL PROGENITOR CELLS; NITRIC-OXIDE SYNTHASE; BONE-MARROW-CELLS; COLONY-STIMULATING FACTOR; INFARCTED MYOCARDIUM; PERIPHERAL-BLOOD; HEMATOPOIETIC PROGENITORS; RAPID MOBILIZATION; CARDIAC-FUNCTION; LOCAL-DELIVERY;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Progenitor cells have the capability to home myocardium in response to ischemia. Cell adhesion markers, in particular integrins, play an important role in the trafficking of stem cells to myocardium. In addition, damaged myocardium secretes several chemokines and growth factors that recruit these precursor cells to the heart. Nitric oxide synthase and hormones can also contribute to the trafficking of progenitor cells to myocardium. The recruitment of stem cells to ischemic myocardium is a complex interchange between cell adhesion markers, chemokines, and growth factors and a better understanding of these processes may lead to more efficient use of stem cells for therapeutic benefit.
引用
收藏
页码：404 / 411
页数：8
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