Development and characterization of a novel microtissue-based 3D human liver fibrosis model for anti-fibrotic drug discovery

被引:0
|
作者
Kostadinova, R. [1 ]
Neelakandhan, A. [1 ]
Kijanska, M. [1 ]
Zapiorkowska, N. [1 ]
Steiert, S. [1 ]
Guye, P. [1 ]
Messner, S. [1 ]
机构
[1] InSphero AG, Schlieren, Switzerland
关键词
D O I
10.1016/S0168-8278(18)30333-7
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
PS-103
引用
收藏
页码:S56 / S56
页数:1
相关论文
共 50 条
  • [31] Novel bioprinted 3D model to human fibrosis investigation
    Petrachi, Tiziana
    Portone, Alberto
    Arnaud, Gaelle Francoise
    Ganzerli, Francesco
    Bergamini, Valentina
    Resca, Elisa
    Accorsi, Luca
    Ferrari, Alberto
    Delnevo, Annalisa
    Rovati, Luigi
    Marra, Caterina
    Chiavelli, Chiara
    Dominici, Massimo
    Veronesi, Elena
    BIOMEDICINE & PHARMACOTHERAPY, 2023, 165
  • [32] A novel tissue-engineered 3D tumor model for anti-cancer drug discovery
    Li, Wenfang
    Hu, Xueyan
    Yang, Shuaitao
    Wang, Shuping
    Zhang, Chenghong
    Wang, Hai
    Cheng, Yuen Yee
    Wang, Yiwei
    Liu, Tianqing
    Song, Kedong
    BIOFABRICATION, 2019, 11 (01)
  • [33] Gli3 is a novel downstream target of miR-200a with an anti-fibrotic role for progression of liver fibrosis in vivo and in vitro
    Li, Li
    Ran, Jianghua
    Li, Lan
    Chen, Gang
    Zhang, Shengning
    Wang, Yingjia
    MOLECULAR MEDICINE REPORTS, 2020, 21 (04) : 1861 - 1871
  • [34] SINGLE NUCLEI RNA-SEQ PROFILING OF FIBROTIC HUMAN PRECISION-CUT LIVER SLICES: A NOVEL METHOD FOR EVALUATING ANTI-FIBROTIC DRUG CANDIDATES
    Ho, Steve
    An, Mahru
    Rao, Vikram
    Turner, Scott
    Decaris, Martin
    Schaub, Johanna
    HEPATOLOGY, 2022, 76 : S438 - S439
  • [35] Human Multilineage 3D Spheroids as a Model of Liver Steatosis and Fibrosis
    Pingitore, Piero
    Sasidharan, Kavitha
    Ekstrand, Matias
    Prill, Sebastian
    Linden, Daniel
    Romeo, Stefano
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (07)
  • [36] Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model
    Ali Kermanizadeh
    Mille L hr
    Martin Roursgaard
    Simon Messner
    Patrina Gunness
    Jens M Kelm
    Peter Møller
    Vicki Stone
    Steffen Loft
    Particle and Fibre Toxicology, 11
  • [37] Applying single-cell profiling to assess drug anti-fibrotic properties in the human precision-cut lung slice model of fibrosis
    Justet, Aurelien
    Mitash, Milay
    Raredon, Sam Micha
    Pineda, Ricardo H.
    Adams, Taylor
    Al Hussein, Nebal
    Ishizuka, Masahiro
    Hahram, Kim
    Khoury, Johad
    Ahangari, Farida
    Xiting, Yang
    Naftali, Kaminski
    Melanie, Koenigshoff
    EUROPEAN RESPIRATORY JOURNAL, 2024, 64
  • [38] Fibrotic Lung Matrix Derived Hydrogels as an In-Vitro 3D Platform for Drug Discovery in Idiopathic Pulmonary Fibrosis
    Davila, J. Fernandez
    Moore, D. W.
    Khan, J.
    Collins, A. C.
    Lemma, M.
    King, C. S.
    Nathan, S. D.
    Rodriguez, L. R.
    Grant, G. M.
    Moran, J. L.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2022, 205
  • [39] Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model
    Kermanizadeh, Ali
    Lohr, Mille
    Roursgaard, Martin
    Messner, Simon
    Gunness, Patrina
    Kelm, Jens M.
    Moller, Peter
    Stone, Vicki
    Loft, Steffen
    PARTICLE AND FIBRE TOXICOLOGY, 2014, 11
  • [40] In vitro Drug Screening Model for Cardiac Fibrosis Using Human Induced Pluripotent Stem Cell Derived Cardiac Tissue Provides Drug Repositioning of Anti-fibrotic Drugs for Cardiac Fibrosis
    Iseoka, Hiroko
    Miyagawa, Shigeru
    Sakai, Yoshiki
    Harada, Akima
    Sawa, Yoshiki
    CIRCULATION, 2019, 140