An injectable drug-loaded hydrogel based on a supramolecular polymeric prodrug

被引：70
|
作者：
Xiong, Lu [1 ]
Luo, Qiaojie [2 ]
Wang, Ying [1 ]
Li, Xiaodong [2 ]
Shen, Zhiquan [1 ]
Zhu, Weipu [1 ]
机构：
[1] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Affiliated Stomatol Hosp, Hangzhou 310006, Zhejiang, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 78期
基金：
中国国家自然科学基金;
关键词：
CLICK CHEMISTRY; ANTICANCER DRUGS; DELIVERY SYSTEMS; CANCER-THERAPY; RELEASE; MICELLES; PH; NANOPARTICLES; PACLITAXEL; MICROSPHERES;
D O I：
10.1039/c5cc06025g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We reported a novel injectable doxorubicin-loaded hydrogel based on host-guest interaction and Schiff's base reaction. A supramolecular polymeric prodrug was prepared through the inclusion of adamantane-modified doxorubicin into the beta-cyclodextrin cavity on the polyaldehyde dextran chain, which was in situ crosslinked by carboxymethyl chitosan.
引用
收藏
页码：14644 / 14647
页数：4
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