A novel and green biomaterial based silver nanocomposite hydrogel: Synthesis, characterization and antibacterial effect

被引：60
|
作者：
Bardajee, Ghasem R. [1 ]
Hooshyar, Zari [1 ]
Rezanezhad, Habib [1 ]
机构：
[1] Payame Noor Univ, Dept Chem, Tehran, Iran
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2012年 / 117卷
关键词：
Silver nanoparticles; Drug delivery; Tetracycline hydrochloride; Hydrogel; Antibacterial effect; NANOPARTICLES; TETRACYCLINE; BIOSYNTHESIS; SALEP;
D O I：
10.1016/j.jinorgbio.2012.06.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the present study, we report a facile and eco-friendly method for the preparation of a novel silver nanocomposite hydrogel (SNH) based on poly(acrylic acid) (PM) grafted onto salep as a water soluble polysaccharide backbone. The presence of inorganic silver nanoparticles (nano-Ag) in the hydrogel was confirmed by thermo-gravimetric (TG) analysis. The TEM images illustrated the presence of embedded nano-Ag throughout the hydrogel matrix. In addition, the transmission electron microscopy (TEM) images showed that the formed nano-Ag had an average particle size of 5-10 nm. The potential of obtained SNH was examined for Tetracycline hydrochloride (TH) release in simulated colon conditions. Lastly, the in vitro antibacterial properties of the obtained optimum sample were successfully evaluated against gram-negative and gram-positive bacteria. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：367 / 373
页数：7
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