Conversion of acyclic nonpeptide CCK antagonists into CCK agonists

被引：4

作者：

Hirst, GC

Queen, KL

Sugg, EE

Willson, TM

机构：

[1] GLAXO WELLCOME INC,RES & DEV,DEPT MED CHEM,RES TRIANGLE PK,NC 27709

[2] GLAXO WELLCOME INC,RES & DEV,DEPT RECEPTOR BIOCHEM,RES TRIANGLE PK,NC 27709

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(97)00062-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The CCK antagonists RP 69758 and (R)-lorglumide were converted into CCK agonists by the introduction of an N-isopropylanilide agonist ''trigger.'' The common structural features of these ligands suggest that nonpeptide agonists and antagonists bind to a common site in the CCK receptor. (C) 1997 Elsevier Science Ltd.

引用

页码：511 / 514

页数：4

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