Conversion of acyclic nonpeptide CCK antagonists into CCK agonists

被引：4
|
作者：
Hirst, GC
Queen, KL
Sugg, EE
Willson, TM
机构：
[1] GLAXO WELLCOME INC,RES & DEV,DEPT MED CHEM,RES TRIANGLE PK,NC 27709
[2] GLAXO WELLCOME INC,RES & DEV,DEPT RECEPTOR BIOCHEM,RES TRIANGLE PK,NC 27709
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 05期
关键词：
D O I：
10.1016/S0960-894X(97)00062-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The CCK antagonists RP 69758 and (R)-lorglumide were converted into CCK agonists by the introduction of an N-isopropylanilide agonist ''trigger.'' The common structural features of these ligands suggest that nonpeptide agonists and antagonists bind to a common site in the CCK receptor. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：511 / 514
页数：4
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