Animal Models for Microbicide Studies

被引：0

作者：

Veazey, Ronald S. ^{[1
]}

Shattock, Robin J. ^{[2
]}

Klasse, Per Johan ^{[3
]}

Moore, John P. ^{[3
]}

机构：

[1] Tulane Univ, Tulane Natl Primate Res Ctr, Div Comparat Pathol, Sch Med, Covington, LA 70433 USA

[2] Univ London Imperial Coll Sci Technol & Med, Infect Dis Sect, London W21PG 13, England

[3] Weill Cornell Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA

来源：

CURRENT HIV RESEARCH | 2012年 / 10卷 / 01期

关键词：

HIV; animal models; HIV transmission; mucosal transmission; vagina; rectum; HUMAN-IMMUNODEFICIENCY-VIRUS; HUMANIZED BLT MICE; VAGINAL SHIV CHALLENGE; NONHUMAN PRIMATE MODEL; T-CELL RESPONSES; SIMIAN-HUMAN; TOPICAL MICROBICIDE; RHESUS MACAQUES; MUCOSAL TRANSMISSION; HIV-1; INFECTION;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There have been encouraging recent successes in the development of safe and effective topical microbicides to prevent vaginal or rectal HIV-1 transmission, based on the use of anti-retroviral drugs. However, much work remains to be accomplished before a microbicide becomes a standard element of prevention science strategies. Animal models should continue to play an important role in pre-clinical testing, with emphasis on safety, pharmacokinetic and efficacy testing.

引用

页码：79 / 87

页数：9

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