Evaluation of Antipyretic, Analgesic and Anti-inflammatory Effects of Nimesulide Injection

被引：0
|
作者：
Wang, C. Y. [1 ]
Wu, M. W. [2 ]
Bourkaib, Nadia [3 ]
Luo, Y. H. [1 ]
Chen, Q. [1 ]
Zhu, J. [1 ]
Dong, X. R. [1 ]
Feng, H. X. [1 ]
机构：
[1] Southwest Univ, Coll Pharmaceut Sci, Chongqing 400716, Peoples R China
[2] Southwest Univ, Coll Anim Sci & Technol, Chongqing 400715, Peoples R China
[3] China Pharmaceut Univ, Dept Pharmaceut, Nanjing 210009, Jiangsu, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2012年 / 31卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Analgesic; Anti-inflammatory; Antipyretic; Injection; Nimesulide; SELECTIVE COX-2 INHIBITOR; OSTEOARTHRITIS; CELECOXIB; MELOXICAM; ISCHEMIA; CELLS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of the present study was to evaluate the antipyretic, analgesic, and anti-inflammatory effects of nimesulide injection, which were studied on peptone-induced fever pathologic model of New Zealand white rabbits; acetic-acid induced writhing on mice and egg white-induced paw edema on rats. Animal experimental results showed that the nimesulide injection had obvious effects of antipyretic, analgesic, and anti-inflammatory, that were as much effective as isometric metamizole sodium injection. Moreover, there was no significant statistical difference between isometric metamizole sodium injection and nimesulide injection (P>0.05). In conclusion, nimesulide injection exhibited remarkable antipyretic, analgesic, and anti-inflammatory effects.
引用
收藏
页码：1412 / 1416
页数：5
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