Evaluation of Antipyretic, Analgesic and Anti-inflammatory Effects of Nimesulide Injection

被引：0

作者：

Wang, C. Y. ^{[1
]}

Wu, M. W. ^{[2
]}

Bourkaib, Nadia ^{[3
]}

Luo, Y. H. ^{[1
]}

Chen, Q. ^{[1
]}

Zhu, J. ^{[1
]}

Dong, X. R. ^{[1
]}

Feng, H. X. ^{[1
]}

机构：

[1] Southwest Univ, Coll Pharmaceut Sci, Chongqing 400716, Peoples R China

[2] Southwest Univ, Coll Anim Sci & Technol, Chongqing 400715, Peoples R China

[3] China Pharmaceut Univ, Dept Pharmaceut, Nanjing 210009, Jiangsu, Peoples R China

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2012年 / 31卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Analgesic; Anti-inflammatory; Antipyretic; Injection; Nimesulide; SELECTIVE COX-2 INHIBITOR; OSTEOARTHRITIS; CELECOXIB; MELOXICAM; ISCHEMIA; CELLS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of the present study was to evaluate the antipyretic, analgesic, and anti-inflammatory effects of nimesulide injection, which were studied on peptone-induced fever pathologic model of New Zealand white rabbits; acetic-acid induced writhing on mice and egg white-induced paw edema on rats. Animal experimental results showed that the nimesulide injection had obvious effects of antipyretic, analgesic, and anti-inflammatory, that were as much effective as isometric metamizole sodium injection. Moreover, there was no significant statistical difference between isometric metamizole sodium injection and nimesulide injection (P>0.05). In conclusion, nimesulide injection exhibited remarkable antipyretic, analgesic, and anti-inflammatory effects.

引用

页码：1412 / 1416

页数：5

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